Still, they aren't as effective at treating schizophrenia, and may have other side effects, such as motor problems, says Roerig.
(Roerig gets research funding from Eli Lilly, the maker of Zyprexa.)Tricyclic antidepressants (TCAs), such as amitriptyline, are linked to weight gain more than other antidepressants or migraine meds.
Thorazine, along with Mellaril (thioridazine), has antihistamine activity, which increases your appetite and is sedating, says James Roerig, associate professor of clinical neuroscience at the University of North Dakota School of Medicine and Health Sciences, in Fargo.
Newer beta-blockers, calcium channel blockers, and ACE inhibitors are less likely to cause weight gain, Dr. Birth-control pills are often blamed for weight gain, but it is largely unwarranted, Dr. In fact, only the long-acting, progestin-only injectable called depot medroxyprogesterone acetate (DMPA) has been consistently linked with weight gain.
Oral corticosteroids, such as Deltasone, are more potent than inhaled forms and carry a higher risk of weight gain, particularly with long-term use.
A 2006 survey of long-term oral-corticosteroid users suggested 60% to 80% had gained weight.
A 60-week study found that, although patients on Prozac shed more than the placebo group (up to 11 pounds in the first six months), they started to regain the weight about halfway through the study. Cheskin says the reason could be that patients develop tolerance to the satiety effect.
"If someone is trying to lose weight, and is on an SSRI for depression, I will often switch to Wellbutrin (bupropion)," which is associated with weight loss, he says.